Prognostic value of basal markers (epidermal growth factor receptor “EGFR” and cytokeratin 5/6) expression in triple-negative invasive breast cancer

Objective: The To distinguish between basal and non-basal subtypes of triple-negative breast cancers based on epidermal growth factor receptor cytokeratin 5/6, to establish the association diagnosis with clinicopathological parameters survival rates.Methods: retrospective study was conducted at Clinical Oncology Nuclear Medicine Department Kafrelsheikh University Hospital Tanta Hospital, Egypt, comprised medical records from January 2014 December 2018 related cases histopathologically proven cancer who had been treated followed up for least 5 years. evaluated using immunohistochemistry Cytokeratin 5/6 expression. Data prognostic factors, overall diseasefree retrieved. analysed SPSS 21.Results: There were 100 patients median age 50 years (inter-quartile range: 35-55.25 years; 22-69 years). 58(58%) pre-menopausal subjects, 15(15%) positive family history, 68(68%) tumour size T2. Basal markers noted in 74(74%) patients. subtype significantly more common aged <50 diagnosis, premenopausal women, nodal status, those grade III tumours, Ki67 proliferation marker >20% (p<0.05). Tumour size, histological lympho-vascular invasion not different groups (p>0.05). worse disease-free rates (p<0.05).Conclusion: Triple-negative expressed and/or found have poor findings, survival.Keywords: Breast neoplasms, antigen, EGFR Receptors, Oncology.